See how the actress's hair and makeup has evolved through the years.
1982
The third generation Hollywood star played Gertie in the sci-fi hit E.T.
1984
She played evil in Firestarter, but the 9-year-old looked angelic with her blond locks and sweet smile.
1988
13-year-old Barrymore sported an '80s perm and brushed up brows.
1990
The Hollywood scenester dyed her hair a buttery blond and added a swipe of matte red lipstick.
1992
The once-troubled teen made her comeback with Poison Ivy and auburn hair. "I find redheads so beautiful," Barrymore has said. "To play in their field is so much fun."
1995
For the Los Angeles premiere of Batman Forever, Barrymore wore a daisy in her stylishly tousled pixie.
1996
Ever-experimental, the 21-year-old Scream star dyed her hair blue-black and lightened her complexion with pale powder.
1997
Drew brought the cute with an edgy version of a Louise Brooks bob.
1998
The Wedding Singer leading lady presented at the Oscars with her signature fresh daisies in her then platinum hair.
2000
At the Academy Awards, the Charlie's Angels doyenne got romantic with sheer rose lips, petal pink cheeks, and a wash of olive eye shadow.
2003
Drew went all out at the London premiere of Charlie's Angels: Full Throttle with a major dusting of Kabuki-style powder.
2003
"Black liner and lashes really make her sparkly eyes come alive," her makeup artist Gucci Westman has said. Sexy beach waves completed the look.
2004
Barrymore swapped her daisies for a gardenia at the 50 First Dates premiere. Said hairstylist Lona Vigi, "She loves hair accessories that are playful and fun, just like her personality."
2005
Red lips and red hair for the Fever Pitch beauty.
2007
For a Versace event, Barrymore let her couture take center stage. "The dress had a busy neckline, so we kept her hair straight and simple," Vigi has said. A strip of false lashes gave her sexy bedroom eyes.
2007
The Music and Lyrics lead - and new face of Cover Girl - named her beauty must-haves as, "concealer, blush and a chocolaty, smoky, smudgy eyeliner."
2009
Barrymore channeled Monroe for the Globes. "She'd been dark for a while, so we brightened her look with this platinum hue," said colorist Tracey Cunningham.
2009
The Grey Gardens star drew inspiration for her premiere hair from her eccentric character's '40s heyday: "I wore a headdress to honor Edie." The gorgeous champagne veil was accented with a beaded flower.
2009
"This is the craziest look I've ever given her!" colorist Tracey Cunningham said of Drew's Whip It premiere look. "I used clear foils and a stencil that I made out of paper to get everything to line up."
2009
For Drew's October InStyle cover, hairstylist Mark Townsend used pomade to add texture to the look. "We didn't want the hair to look to done," he said. "We wanted the hair to have a little edge to it."
2010
Better than ever! The Going the Distance lead turned heads with a long ombre mane with lots of volume and cool pink blush courtesy of her longtime makeup artist, Debra Ferullo.
2011
Barrymore switched up her look with auburn locks. "It's a warm red," said colorist Tracey Cunningham. "It looks really natural on her skin tone. She's totally committed to it - we've been talking about it for a couple of months at least."
2012
The newly-engaged star pinned back her ombre locks for the premiere of The Big Miracle.
2012
Barrymore showed off her favorite hue at the Marni for H&M launch: "I heard somebody talking smack about ombre hair, and I was like, 'Oh don't you go talking s- about that, girlfriend.' I just love it!"
2012
Back to blond at a New York City Ballet gala! "I love Drew's lighter look, and so does she," her colorist Cunningham told InStyle.com. "I used Redken Chromatics to achieve the beautiful blond color. Her hair looks and feels amazing, and complements her skin beautifully."
2012
The new mom showed off auburn locks an an L.A. event for Bulgari.
2013
Drew Barrymore lightened up for 2013 LACMA Art & Film Gala. The star arrived brighter and blonder with honey-hued tresses and a soft pink lip.
2014
For the launch party of her photography book, Find it in Everything, a pregnant Barrymore wowed with green eyeshadow and straight, loose hair.
2015
Barrymore, best known for her roles in E.T., Charlie's Angels, and a slew of other films, has also conquered the makeup realm with her Flower Beauty cosmetics line. "My first favorite beauty moment was when I was a kid watching women get ready in a makeup room—it was like this secret society where they all had eyelash curlers and rollers in their hair," she says.
2016
Barrymore got experimental with her makeup at BeautyCon in N.Y.C., complementing her hazel eyes with a bold steel blue liner and a matte peach lip.
2017
The Santa Clarita Diet star rocked natural beachy waves and a glossy lip to a special screening of the Netflix original series.